1. Why is patient recruitment so challenging today?
Patient recruitment faces hurdles such as trial hesitancy, complex eligibility criteria, and logistical barriers like travel distance and time commitment. Patients often fear side effects, worry about being “guinea pigs,” or lack clarity on what participation entails. These factors contribute to low enrollment rates.
2. What role does data integration play in recruitment success?
Integrating real-world data (RWD) and feasibility tools helps sponsors predict recruitment outcomes, streamline site selection, and reduce operational delays. AI-driven simulations and real-time data refreshes enable dynamic adjustments to inclusion/exclusion criteria and recruitment strategies.
3. What is the “third generation” of patient recruitment?
The third generation moves beyond traditional site-based and direct-to-patient advertising. It leverages proprietary data, RWD, tokenization, and AI to identify protocol-matching patients across a broader ecosystem, including healthcare practices not actively involved in research.
References
1 Center for Information and Study on Clinical Research Participation (CISCRP) 2025 Perceptions and Insights Study. Available from https://www.ciscrp.org/professional-services/perceptions-and-insights-studies [Accessed Nov. 14, 2025]


